TGTX News & Events

Precision BioSciences (DTIL) announced the achievement of a clinical milestone under its license agreement with TG Therapeutics (TGTX). The milestone payment for azercabtagene zapreleucel was triggered by progress of a Phase 1 clinical trial of azer-cel in progressive forms of multiple sclerosis. As a result of this milestone event, Precision will receive $7.5M in proceeds, inclusive of $5.25M cash and $2.25M for the purchase of 201,504 shares of Precision common stock by TG Therapeutics at $11.17 per share, pursuant to the terms of the companies' license agreement. Existing cash and cash equivalents, inclusive of the azer-cel milestone proceeds, continued fiscal and operating discipline, and availability of the ATM facility, are expected to provide sufficient cash runway through 2028. In January 2024, Precision BioSciences announced a licensing deal, granting TG Therapeutics exclusive worldwide rights to develop and commercialize azer-cel in autoimmune diseases and other non-oncology indications. Under the agreement, Precision received upfront and potential near-term economics and remains eligible for additional development, regulatory, and commercial milestone payments, as well as royalties on net sales. Precision is eligible to receive up to $288M in additional milestone payments as well as high-single-digit to low-double-digit royalties on net sales.

Cash, cash equivalents and investment securities were $199.5 million as of December 31, 2025. We anticipate that our cash, cash equivalents and investment securities as of December 31, 2025, combined with the projected revenues from BRIUMVI, will be sufficient to fund our business based on our current operating plan.

Full year 2026 target total global revenue of approximately $875-$900M, including BRIUMVI U.S. net product revenue of approximately $825-$850M; Q1 2026 target BRIUMVI U.S. net product revenue of approximately $185-$190M. Full year 2026 target operating expense, defined as R&D and SG&A, of approximately $350 million excluding non-cash compensation, in addition to approximately $100 million in expenses associated with the subcutaneous BRIUMVI manufacturing costs and secondary manufacturer start-up costs. Announce pivotal topline data for ENHANCE trial combining Day 1 and Day 15 doses of IV BRIUMVI mid-year 2026; Present preliminary Phase 1 azer-cel data in Progressive MS in the second half of 2026; Announce pivotal topline data for subcutaneous BRIUMVI year-end 2026/1Q 2027; Commence registration-directed trial for BRIUMVI in an indication outside of MS; Commence additional exploratory studies for BRIUMVI and azer-cel in autoimmune disease.

Reports Q4 revenue $192.6M, consensus $193.34M. Michael Weiss, CEO, stated, "2025 was a strong year of execution for TG Therapeutics, driven by continued momentum for BRIUMVI and meaningful progress across our organization. BRIUMVI delivered significant year-over-year growth in the U.S., supported by increasing adoption and expanding global availability, while we advanced multiple late-stage clinical programs and strengthened our financial position. As we enter 2026, we are focused on building on this foundation. With strong financial guidance, several important clinical milestones ahead, and a disciplined approach to operations, we believe we are well positioned to continue delivering value for patients, healthcare providers, and shareholders."