Spyre Therapeutics Inc (SYRE) has a current Price-to-Book (P/B) ratio of 6.18. Compared to its 3-year average P/B ratio of -99.72, the current P/B ratio is approximately -106.20% higher. Relative to its 5-year average P/B ratio of -57.39, the current P/B ratio is about -110.77% higher. Spyre Therapeutics Inc (SYRE) has a Forward Free Cash Flow (FCF) yield of approximately -6.82%. Compared to its 3-year average FCF yield of -100.36%, the current FCF yield is approximately -93.20% lower. Relative to its 5-year average FCF yield of -104.82%, the current FCF yield is about -93.49% lower.

Competitors Valuation Multiple

AI Analysis

The average P/S ratio for SYRE competitors is 3.78, providing a benchmark for relative valuation. Spyre Therapeutics Inc Corp (SYRE.O) exhibits a P/S ratio of 0.00, which is -100% above the industry average. Given its robust revenue growth of %, this premium appears unsustainable.

P/E

P/S

EV/EBITDA

EV/EBIT

Earnings Growth

Market Cap

Performance Decomposition

AI Analysis

Market capitalization of SYRE increased by 0.00% over the past 1 year(s). The primary factor behind the change was an decrease in Unknown from 0.00 to 0.00.

The secondary factor is the Unknown, contributed 0.00% to the performance.

Overall, the performance of SYRE in the past 1 year(s) is driven by Unknown.

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Frequently Asked Questions

Is SYRE currently overvalued or undervalued?

What is Spyre Therapeutics Inc (SYRE) fair value?

SYRE's fair value is calculated using relative valuation, based on historical P/E and P/S ranges and their premiums/discounts relative to a competitor average, adjusted by weights. The fair price of Spyre Therapeutics Inc (SYRE) is between to according to relative valuation method.

How does SYRE's valuation metrics compare to the industry average?

The average P/S ratio for SYRE's competitors is 3.78, providing a benchmark for relative valuation. Spyre Therapeutics Inc Corp (SYRE) exhibits a P/S ratio of 0.00, which is -100.00% above the industry average. Given its robust revenue growth of %, this premium appears unsustainable.

What is the current P/B ratio for Spyre Therapeutics Inc (SYRE) as of Mar 02 2026?

As of Mar 02 2026, Spyre Therapeutics Inc (SYRE) has a P/B ratio of 6.18. This indicates that the market values SYRE at 6.18 times its book value.

What is the current FCF Yield for Spyre Therapeutics Inc (SYRE) as of Mar 02 2026?

As of Mar 02 2026, Spyre Therapeutics Inc (SYRE) has a FCF Yield of -6.82%. This means that for every dollar of Spyre Therapeutics Inc's market capitalization, the company generates -6.82 cents in free cash flow.

What is the current Forward P/E ratio for Spyre Therapeutics Inc (SYRE) as of Mar 02 2026?

As of Mar 02 2026, Spyre Therapeutics Inc (SYRE) has a Forward P/E ratio of -10.43. This means the market is willing to pay $-10.43 for every dollar of Spyre Therapeutics Inc's expected earnings over the next 12 months.

What is the current Forward P/S ratio for Spyre Therapeutics Inc (SYRE) as of Mar 02 2026?

As of Mar 02 2026, Spyre Therapeutics Inc (SYRE) has a Forward P/S ratio of 0.00. This means the market is valuing SYRE at $0.00 for every dollar of expected revenue over the next 12 months.

SYRE Valuation