CTSO Overview

Company Presentation: CytoSorbents Corporation will present at the Jefferies Global Healthcare Conference from November 17-20, 2025, with a specific presentation scheduled for November 18 at 12:30 PM GMT.

Product Overview: The company specializes in blood purification technologies for critical care, with its lead product, CytoSorb, approved in the EU and used in over 70 countries to remove toxins and inflammatory agents from blood.

Regulatory Developments: CytoSorbents is pursuing FDA approval for its investigational DrugSorb™-ATR system, aimed at reducing perioperative bleeding in high-risk surgeries, and has received Breakthrough Device Designations for specific anticoagulant removals.

Forward-Looking Statements: The press release includes forward-looking statements regarding the company's plans and regulatory submissions, cautioning that actual results may differ due to various risks and uncertainties.

Analyst Recommendation: HC Wainwright & Co. maintains a Neutral recommendation for Cytosorbents (NasdaqCM:CTSO) as of November 14, 2025, with a projected one-year price target of $5.10/share, indicating a potential upside of 672.73% from its current price of $0.66/share.

Projected Revenue and EPS: Cytosorbents is expected to see a significant increase in annual revenue, projected at $122 million, which represents a 237.10% growth, alongside a projected non-GAAP EPS of 0.17.

Fund Sentiment: There are currently 73 funds reporting positions in Cytosorbents, reflecting an 8.96% increase in ownership over the last quarter, with total institutional shares rising by 1.15% to 18,005K shares.

Shareholder Activity: Notable changes in shareholder allocations include Avenir increasing its stake slightly, while Skylands Capital and Neuberger Berman Group both reduced their holdings significantly over the last quarter.

Financial Performance: CytoSorbents Corporation reported a 10% year-over-year revenue increase to $9.5 million in Q3 2025, with improved gross margins of 70% and a reduced operating loss of $2.9 million.

Strategic Initiatives: The company implemented a Workforce and Cost Reduction Program aimed at achieving cash-flow breakeven by Q1 2026, alongside an amended credit agreement providing an additional $2.5 million in funding.

Regulatory Progress: CytoSorbents submitted a De Novo pre-submission package for its DrugSorb™-ATR device to the FDA, with a formal application expected in Q1 2026 and a regulatory decision anticipated by mid-2026.

Clinical Advancements: Recent clinical data and presentations highlighted the effectiveness of CytoSorb's therapies in managing sepsis and anticoagulant removal during cardiac surgery, reinforcing the company's commitment to improving patient outcomes.

Company Participation in Conference: CytoSorbents Corporation's CEO Dr. Phillip Chan and CFO Mr. Peter Mariani will attend the Jefferies Global Healthcare Conference in London on November 18-19, 2025, for one-on-one meetings with investors.

About CytoSorbents Corporation: The company specializes in blood purification technologies for treating life-threatening conditions in intensive care and cardiac surgery, with its lead product, CytoSorb®, approved in the EU and used in over 70 countries.

Regulatory Developments: CytoSorbents is developing the DrugSorb™-ATR system to reduce perioperative bleeding in high-risk surgeries, which has received FDA Breakthrough Device Designations but is not yet approved in the U.S. or Canada.

Forward-Looking Statements: The press release includes forward-looking statements regarding the company's plans and regulatory submissions, cautioning that actual results may differ due to various risks and uncertainties.