The Short List: Current Top 10 Most Shorted Stocks
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 26 2025
0mins
Should l Buy NTLA?
Source: Benzinga
Reasons for Short Selling: Traders short stocks to either bet on a decline in value or to profit from potential short squeezes, where rising prices force short sellers to buy back shares, creating a feedback loop of increasing demand.
Characteristics of Heavily Shorted Stocks: Stocks become heavily shorted when experienced traders believe they are overvalued, indicating serious risks, while retail traders may see high short interest as an opportunity for quick gains.
Top Heavily Shorted Stocks: As of November 26, 2025, the most shorted stocks include The Wendy's Co. (WEN) at 55.36% short interest, followed by Cambium Networks Corp. (CMBM) and Lucid Group, Inc. (LCID).
Risks and Volatility: While short squeezes can lead to significant gains, they come with high risks and volatility, necessitating careful monitoring and due diligence by traders.
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Analyst Views on NTLA
Wall Street analysts forecast NTLA stock price to rise
22 Analyst Rating
9 Buy
12 Hold
1 Sell
Moderate Buy
Current: 13.605
Low
4.00
Averages
16.50
High
54.00
Current: 13.605
Low
4.00
Averages
16.50
High
54.00
About NTLA
Intellia Therapeutics, Inc. is a clinical-stage gene editing company focused on developing medicine with CRISPR-based therapies. CRISPR is a gene editing technology which is also sometimes referred to as CRISPR/Cas or CRISPR/Cas9 when referring to the use of CRISPR technology with the Cas9 enzyme. Its in vivo product candidates address genetic diseases by deploying its technologies, including CRISPR/Cas9 delivered by LNPs, as the therapy for diseases with high unmet need. Its lead in vivo product candidates, nexiguran ziclumeran (nex-z or NTLA-2001) for the treatment of transthyretin (ATTR) amyloidosis and NTLA-2002 for the treatment of hereditary angioedema (HAE), are the first CRISPR-based therapy candidates to be administered systemically, via intravenous (IV) infusion, for precision editing of a gene in a target tissue in humans. For its ex vivo product candidates, it applies its technologies to create engineered cell therapies to address immuno-oncology and autoimmune diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Intellia Presents New Research at AAAAI Meeting
- Clinical Trial Results: In a pooled Phase 1/2 analysis involving 32 hereditary angioedema (HAE) patients, a single 50 mg dose of lonvo-z resulted in a mean monthly attack rate of ≤0.2, representing a 96% reduction from baseline, highlighting the potential long-term safety and efficacy of lonvo-z.
- Evolving Treatment Goals: Among 28 patients who received lonvo-z, 86% achieved attack-free and long-term prophylaxis-free status after more than six months of follow-up, indicating a strong alignment between patient needs for reduced treatment burden and clinical objectives.
- Biological Modeling Study: Research indicates that significant C1-esterase inhibitor deficiency in HAE patients leads to excessive plasma kallikrein generation, with models showing that an 85% reduction in prekallikrein can normalize kallikrein and bradykinin levels, supporting the clinical efficacy of lonvo-z.
- Patient Challenge Survey: A survey of 100 HAE patients revealed that 34% experienced at least one attack per month, with only 20% being attack-free in the past year, underscoring the demand for lonvo-z as patients seek to eliminate chronic medication use to improve treatment outcomes.
See More
INTELLIA THERAPEUTICS STOCK RISES 2% FOLLOWING US FDA'S LIFTING OF CLINICAL HOLD ON HEART DISEASE GENE THERAPY TRIAL
- Stock Performance: Intelia Therapeutics shares increased by 2% following a positive development in their clinical trial results.
- Clinical Trial Focus: The trial is centered on gene therapy for treating heart disease, specifically targeting a gene associated with the condition.
See More
Wall Street Analysts Adjust Ratings
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- Market Focus: Analysts' views on TGT stock have garnered investor attention, indicating differing expectations for its future performance, which could influence investment decisions.
- Impact of Rating Changes: Changes in ratings may affect investor confidence, directly impacting trading volumes and price fluctuations of TGT stock, especially amid increasing market uncertainty.
- Access More Information: Investors can visit the analyst ratings page to view a complete overview of all rating changes, enabling more informed investment decisions.
See More
Cathie Wood Continues to Add to Growth Stock Positions
- MercadoLibre Financial Analysis: MercadoLibre reported a 45% year-over-year increase in net revenue and financial income to $8.8 billion in Q4, yet its operating profit rose only 8% due to a 50% spike in operating expenses, resulting in net income falling short of Wall Street expectations for the third consecutive quarter, indicating pressure on profitability.
- Intellia Therapeutics Positive Development: Intellia Therapeutics' stock surged 12% after the FDA lifted the clinical hold on its investigational new drug application, although the shares remain below their October highs, reflecting a mix of market optimism and inherent risks regarding its future gene-editing therapies.
- Generate Biomedicines IPO Performance: Generate Biomedicines raised $400 million in its IPO but closed at $12.91 on its first trading day, down from its $16 offering price, indicating cautious market sentiment towards its AI-driven drug development approach, with Cathie Wood continuing to buy shares during this period.
- Market Competition and Investment Pressure: MercadoLibre faces competitive challenges in Brazil, compelling it to significantly lower minimum order requirements for free shipping; while its long-term investment strategy appears sound, the short-term decline in earnings expectations may adversely affect its stock performance.
See More
Wall Street Analysts Adjust GE Stock Ratings
- Analyst Rating Changes: Top Wall Street analysts have adjusted their outlook on General Electric (GE) stock, indicating a shift in market sentiment, although specific rating changes were not detailed in the report.
- Market Reaction Insight: While specific upgrades or downgrades were not provided, the change in analysts' perspectives could influence investor decisions, particularly among those considering purchasing GE stock.
- Source of Information: This information is provided by Benzinga, highlighting the significance of analyst ratings in market dynamics, and investors should pay attention to these changes to make informed investment choices.
- Overall Market Trends: Changes in analyst ratings often signal market expectations regarding a company's future performance, thus investors should closely monitor these updates to seize potential investment opportunities.
See More
Intellia Therapeutics FDA Lifts Clinical Hold on Nexizuran Trials
- Clinical Trial Progress: Intellia Therapeutics announced that the FDA has lifted the clinical hold on its phase 3 MAGNITUDE trial for transthyretin amyloidosis with cardiomyopathy (ATTR-CM), resulting in a 12% stock price increase on Monday, reflecting renewed market confidence in the drug.
- Historical Context: The clinical holds were imposed in October due to observed Grade 4 liver transaminase elevations and increased total bilirubin in a patient treated with nex-z, but both the MAGNITUDE and MAGNITUDE-2 trials have had their holds lifted, indicating progress in addressing safety concerns.
- Partnership Dynamics: The development of nex-z is in collaboration with Regeneron Pharmaceuticals, highlighting a joint effort to provide new treatment options for patients suffering from hereditary transthyretin amyloidosis with polyneuropathy, which could enhance patient outcomes.
- Financial Performance: Intellia reported a GAAP EPS of -$0.83 for Q4 2025, beating expectations by $0.12, while revenue reached $23.02M, exceeding forecasts by $10.85M, showcasing the company's potential in research and market expansion.
See More
Intellia Presents New Research at AAAAI Meeting
- Clinical Trial Results: In a pooled Phase 1/2 analysis involving 32 hereditary angioedema (HAE) patients, a single 50 mg dose of lonvo-z resulted in a mean monthly attack rate of ≤0.2, representing a 96% reduction from baseline, highlighting the potential long-term safety and efficacy of lonvo-z.
- Evolving Treatment Goals: Among 28 patients who received lonvo-z, 86% achieved attack-free and long-term prophylaxis-free status after more than six months of follow-up, indicating a strong alignment between patient needs for reduced treatment burden and clinical objectives.
- Biological Modeling Study: Research indicates that significant C1-esterase inhibitor deficiency in HAE patients leads to excessive plasma kallikrein generation, with models showing that an 85% reduction in prekallikrein can normalize kallikrein and bradykinin levels, supporting the clinical efficacy of lonvo-z.
- Patient Challenge Survey: A survey of 100 HAE patients revealed that 34% experienced at least one attack per month, with only 20% being attack-free in the past year, underscoring the demand for lonvo-z as patients seek to eliminate chronic medication use to improve treatment outcomes.
See More
INTELLIA THERAPEUTICS STOCK RISES 2% FOLLOWING US FDA'S LIFTING OF CLINICAL HOLD ON HEART DISEASE GENE THERAPY TRIAL
- Stock Performance: Intelia Therapeutics shares increased by 2% following a positive development in their clinical trial results.
- Clinical Trial Focus: The trial is centered on gene therapy for treating heart disease, specifically targeting a gene associated with the condition.
See More
Wall Street Analysts Adjust Ratings
- Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several companies, including upgrades, downgrades, and initiations, reflecting varying market perceptions of these firms.
- Market Focus: Analysts' views on TGT stock have garnered investor attention, indicating differing expectations for its future performance, which could influence investment decisions.
- Impact of Rating Changes: Changes in ratings may affect investor confidence, directly impacting trading volumes and price fluctuations of TGT stock, especially amid increasing market uncertainty.
- Access More Information: Investors can visit the analyst ratings page to view a complete overview of all rating changes, enabling more informed investment decisions.
See More
Cathie Wood Continues to Add to Growth Stock Positions
- MercadoLibre Financial Analysis: MercadoLibre reported a 45% year-over-year increase in net revenue and financial income to $8.8 billion in Q4, yet its operating profit rose only 8% due to a 50% spike in operating expenses, resulting in net income falling short of Wall Street expectations for the third consecutive quarter, indicating pressure on profitability.
- Intellia Therapeutics Positive Development: Intellia Therapeutics' stock surged 12% after the FDA lifted the clinical hold on its investigational new drug application, although the shares remain below their October highs, reflecting a mix of market optimism and inherent risks regarding its future gene-editing therapies.
- Generate Biomedicines IPO Performance: Generate Biomedicines raised $400 million in its IPO but closed at $12.91 on its first trading day, down from its $16 offering price, indicating cautious market sentiment towards its AI-driven drug development approach, with Cathie Wood continuing to buy shares during this period.
- Market Competition and Investment Pressure: MercadoLibre faces competitive challenges in Brazil, compelling it to significantly lower minimum order requirements for free shipping; while its long-term investment strategy appears sound, the short-term decline in earnings expectations may adversely affect its stock performance.
See More
Wall Street Analysts Adjust GE Stock Ratings
- Analyst Rating Changes: Top Wall Street analysts have adjusted their outlook on General Electric (GE) stock, indicating a shift in market sentiment, although specific rating changes were not detailed in the report.
- Market Reaction Insight: While specific upgrades or downgrades were not provided, the change in analysts' perspectives could influence investor decisions, particularly among those considering purchasing GE stock.
- Source of Information: This information is provided by Benzinga, highlighting the significance of analyst ratings in market dynamics, and investors should pay attention to these changes to make informed investment choices.
- Overall Market Trends: Changes in analyst ratings often signal market expectations regarding a company's future performance, thus investors should closely monitor these updates to seize potential investment opportunities.
See More
Intellia Therapeutics FDA Lifts Clinical Hold on Nexizuran Trials
- Clinical Trial Progress: Intellia Therapeutics announced that the FDA has lifted the clinical hold on its phase 3 MAGNITUDE trial for transthyretin amyloidosis with cardiomyopathy (ATTR-CM), resulting in a 12% stock price increase on Monday, reflecting renewed market confidence in the drug.
- Historical Context: The clinical holds were imposed in October due to observed Grade 4 liver transaminase elevations and increased total bilirubin in a patient treated with nex-z, but both the MAGNITUDE and MAGNITUDE-2 trials have had their holds lifted, indicating progress in addressing safety concerns.
- Partnership Dynamics: The development of nex-z is in collaboration with Regeneron Pharmaceuticals, highlighting a joint effort to provide new treatment options for patients suffering from hereditary transthyretin amyloidosis with polyneuropathy, which could enhance patient outcomes.
- Financial Performance: Intellia reported a GAAP EPS of -$0.83 for Q4 2025, beating expectations by $0.12, while revenue reached $23.02M, exceeding forecasts by $10.85M, showcasing the company's potential in research and market expansion.
See More
